Dynamic Interactive Software to Enhance Understanding of Animal Cell Metabolism For Recombinant Protein Production

Project Title

Dynamic Interactive Software to Enhance Understanding of Animal Cell Metabolism For Recombinant Protein Production

Project Leader

Prof John Barford

School / Dept

SENG / CENG

Project Duration

Sept 2003 - Jun 2006

Project Description

Animal cells play an important role in producing high value, recombinant protein products. They include many different cell types and bioreactors. The ability to compare these cells and cultivation methods results in a fruitful learning experience. This project developed dynamic interactive software that described production of recombinant protein products from animal cells. It  allowed students to work out the effect of varying uptake rates of major substrates and nutrients, and the impact these had on internal metabolism and the resultant protein based end products. In addition, variations in different operating conditions (batch, fed-batch and continuous cultivation) and their impact on product yields and production rates could be examined in detail.

Project Outcome

• An existing Fortran code was successfully transferred to a different interface based ob VB Excel.

• A beta version was evaluated by CENG students in CENG361 in Spring 2005.

Status

Completed

Project Documents
(Only accessible by HKUST users)

• Project Plan
• Progress Report: First | Second | Third |
• Final Report

Adaptation

Full Project